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The analgesic activity of Nipazol is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).

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This indicates that Nipazol slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
Forty patients were treated with either Nipazol suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
Forty patients were treated with either Nipazol suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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You may not be able to take Nipazol, or you may require a dosage adjustment,
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Forty patients were treated with either Nipazol suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
Nipazol is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Other medicines�Although certain medicines should not be used together at all,
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Nipazol has not been shown to cause histamine release. At therapeutic doses, Nipazol has no effect on heart rate,
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Nipazol may not work as well and may require higher doses to obtain.
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The product information for Nipazol states that convulsions have been reported in patients using Nipazol at the recommended dose levels and that the risk
safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Nipazol has been shown to cause harm to the fetus.
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These mechanisms may contribute independently to the overall analgesic profile of Nipazol.
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Nipazol may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Nipazol group.
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